This Week in The Journal
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چکیده
Costanza Angelini, Alessandro Morellato, Annalisa Alfieri, Lisa Pavinato, Tiziana Cravero, et al. (see pages [7183–7200][1]) The postsynaptic density (PSD) of excitatory synapses contains an extraordinary number proteins, including AMPA and NMDA receptors, accessory proteins that regulate
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This Week in The Journal
Rather than being distributed evenly throughout the plasma membrane, cellular signaling proteins are concentrated in lipid rafts, which are enriched in sphingolipids and cholesterol. Lipid rafts are particularly dense in neuronal membranes, as are their associated signaling proteins, which direct neuronal differentiation. Palmitoylated proteins aggregate in the detergent-resistant membrane (DRM...
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Opioid drugs and our brain’s endogenous opioids work primarily at mu-type opioid receptors ( R) to dampen pain signals. But because the R is expressed throughout the brain and body, R agonists can cause side effects ranging from constipation to addiction. The related delta-type opioid receptor ( R), in contrast, has more limited expression, but it is found in nociceptive sensory neurons, making...
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Most neurons in the external segment of the globus pallidus (GPe) contribute to the indirect pathway from the dorsal striatum to the output nuclei of the basal ganglia, relaying information from the striatum to the subthalamic nucleus. But 25% of GPe neurons project back to the striatum. These neurons, called arkypallidal neurons, were recently proposed to cancel movements that are in the prepa...
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When an action potential enters a synaptic terminal, voltage-gated calcium channels open, allowing calcium ions to enter and promote synaptic vesicle release. How many vesicles are released depends on the number of release sites and the density and location of calcium channels. If channels are close to release sites, incoming ions quickly bind to vesicle-associated calcium sensors, and relative...
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The critical role of the hippocampus in episodic memory has long been recognized. In particular, the hippocampus is thought to encode spatial, temporal, and semantic relationships among objects and events (Eichenbaum and Cohen, 2014, Neuron 83:764). Numerous human and rodent studies have provided support for this hypothesis. First, the discovery of place cells, which exhibit changes in firing r...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2022
ISSN: ['0270-6474', '1529-2401']
DOI: https://doi.org/10.1523/jneurosci.twij.42.38.2022